20. Acecainide

Nomenclature

CAS number: 32795-44-1
4-(Acetylamino)-N-[2-(diethylamino)ethyl]benzamide; 4′-[[2-(diethylamino)ethyl]carbamoyl]acetanilide; N-acetylprocainamide; NAPA.
C15H23N3O2; mol wt 277.36.
C 64.96%, H 8.36%, N 15.15%, O 11.54%.

Description and references

Metabolite of procainamide, q.v. Prepn: E. C. Schreiber, DE 2062978 (1971 to Squibb), C.A. 75, 76427 (1972). Pharmacokinetics: M. Wierzchowiecki et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 18, 272 (1980). Clinical pharmacology and antiarrhythmic efficacy: J. Kluger et al., Am. J. Cardiol. 45, 1250 (1980); R. A. Winkle et al., ibid. 47, 123 (1981). HPLC determn in plasma: D. Raphanaud et al., Ther. Drug Monit. 8, 365 (1986). Review of pharmacology and therapeutic potential: D. W. G. Harron, R. N. Brogden, Drugs 39, 720-740 (1990).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 34118-92-8
ASL-601.
C15H23N3O2.HCl; mol wt 313.82.
C 57.41%, H 7.71%, N 13.39%, O 10.20%, Cl 11.30%.

Properties

Crystals, mp 190-193°.

Therapeutic Category

Antiarrhythmic.

Keywords

Antiarrhythmic