23. Acediasulfone

Nomenclature

CAS number: 80-03-5
N-[4-[(4-Aminophenyl)sulfonyl]phenyl]glycine; N-p-sulfanilylphenylglycine; p-amino-p′-(carboxymethylamino)diphenyl sulfone; 4-carboxymethylamino-4′-aminodiphenylsulfone; diaminodiphenylsulfone-N-acetic acid.
C14H14N2O4S; mol wt 306.34.
C 54.89%, H 4.61%, N 9.14%, O 20.89%, S 10.47%.

Description and references

Prepn: Jackson, J. Am. Chem. Soc. 70, 680 (1948); CH 254803 and CH 278482 (1949, 1952, to Cilag Ltd.); Rawlins, US 2589211 (1952 to Parke, Davis).

Chemical structure

Properties

Crystals, mp 194°. Sol in methanol, dil sodium hydroxide, acetone.

Derivative

Sodium salt.

Nomenclature

CAS number: 127-60-6
Sulfon-Cilag.
C14H13N2NaO4S; mol wt 328.32.
C 51.22%, H 3.99%, N 8.53%, Na 7.00%, O 19.49%, S 9.77%.

Derivative

Morpholine salt.

Nomenclature

Bentrofene (Cilag-Chemie).
C18H23N3O5S; mol wt 393.46.
C 54.95%, H 5.89%, N 10.68%, O 20.33%, S 8.15%.

Description and references

Prepn: Martin, Habicht, US 2751382 (1956 to Cilag Ltd.).

Properties

Glittering crystals, mp 133-135° (dec).

Therapeutic Category

Antibacterial.

Keywords

Antibacterial (Synthetic); Sulfones