45. ε-Acetamidocaproic Acid

Nomenclature

CAS number: 57-08-9
6-(Acetylamino)hexanoic acid; 6-acetamidohexanoic acid; acetaminocaproic acid; acexamic acid; N-acetyl-6-aminohexanoic acid.
C8H15NO3; mol wt 173.21.
C 55.47%, H 8.73%, N 8.09%, O 27.71%.

Description and references

Prepn: Offe, Z. Naturforsch. 2b, 182 (1947); FR M2332 (1964 to Rowa), C.A. 61, 577b (1964). Anti-inflammatory activity of salts: O. Guillard et al., Pharmacology 34, 296 (1987). Clinical comparison with ranitidine in gastroduodenal ulcer: M. J. Varas Lorenzo, Curr. Ther. Res. 39, 19 (1986).

Chemical structure

Properties

Crystals from acetone, mp 104-105.5° (FR M2332), mp 112° (Offe).

Derivative

Sodium salt.

Nomenclature

CAS number: 7234-48-2
Plastenan (Isopharm).
C8H14NNaO3; mol wt 195.19.
C 49.23%, H 7.23%, N 7.18%, Na 11.78%, O 24.59%.

Derivative

Zinc salt.

Nomenclature

CAS number: 70020-71-2
Zinc acexamate; Copinal (Vinas).
C16H28N2O6Zn; mol wt 409.81.
C 46.89%, H 6.89%, N 6.84%, O 23.42%, Zn 15.96%.

Therapeutic Category

Anti-inflammatory; zinc salt as antiulcerative.

Keywords

Anti-inflammatory (Nonsteroidal)

Zinc Acexamate: Antiulcerative