48. Acetaminosalol

Nomenclature

CAS number: 118-57-0
2-Hydroxybenzoic acid 4-(acetylamino)phenyl ester; p-acetamidophenyl salicylate; acetylaminophenyl salicylate; acetyl-p-aminosalol; p-acetylaminophenol salicylic acid ester; phenetsal.
C15H13NO4; mol wt 271.27.
C 66.41%, H 4.83%, N 5.16%, O 23.59%.

Description and references

Prepn: Brewster, J. Am. Chem. Soc. 40, 1136 (1918).

Chemical structure

Properties

Crystals from hot ethanol, mp 187°. Practically insol in petr ether, cold water, more sol in warm water. Sol in alcohol, ether, benzene. Incompatible with alkalies and alkaline solns which dissolve it with decompn. The alkaline soln gradually becomes blue when boiled, the blue color being discharged upon continued boiling and again produced upon cooling and exposure to air.

Therapeutic Category

Analgesic; antipyretic.

Therapeutic Category (Veterinary)

Analgesic; antipyretic.

Keywords

Antipyretic; Analgesic; Non-opioids; Salicylic Acid Derivatives