95. Acetylleucine

Nomenclature

CAS number: 99-15-0
N-Acetylleucine; acetyl-dl-leucine; α-acetamidoisocaproic acid; Tanganil (Fabre).
C8H15NO3; mol wt 173.21.
C 55.47%, H 8.73%, N 8.09%, O 27.71%.

Description and references

Prepn: E. Fisher, Ber. 34, 433 (1901); W. C. Cahill, I. F. Burton, J. Biol. Chem. 132, 161 (1940); H. R. Snyder et al., J. Am. Chem. Soc. 67, 310 (1945). Effects on central vestibular neurons: N. Vibert, P.-P. Vidal, Eur. J. Neurosci. 13, 735 (2001).

Chemical structure

Properties

Large, flat needles, mp 160-161°. Sol in water, alcohol.

Derivative

Monoethanolamine salt.

Nomenclature

CAS number: 149-90-6
RP-7452.
C8H15NO3.C2H7NO; mol wt 234.29.
C 51.26%, H 9.46%, N 11.96%, O 27.32%.

Description and references

Prepn: P. Gailliot et al., US 2941924 (1960 to Rhne-Poulenc).

Properties

Crystals, mp ≈150°. Soly in water: >20%; in alcohol: ≈1%.

Therapeutic Category

Antivertigo agent.

Keywords

Antivertigo