98. N-Acetylpenicillamine

Nomenclature

CAS number: 15537-71-0
N-Acetyl-3-mercapto-d-valine.
C7H13NO3S; mol wt 191.25.
C 43.96%, H 6.85%, N 7.32%, O 25.10%, S 16.77%.

Description and references

Prepn: Crooks in The Chemistry of Penicillin (Princeton Univ. Press, 1949) p 470; Sheehan et al., US 2477148 and US 2496416 (1949, 1950, both to Merck & Co.).

Chemical structure

Derivative

dl-Form.

Properties

Crystals from hot water, mp 183°.

Derivative

d-Form.

Properties

Crystals from water, mp 189-190°; [α]D25 +18° (50% ethanol).