99. Acetylpheneturide

Nomenclature

CAS number: 13402-08-9
N-[(Acetylamino)carbonyl]-α-ethylbenzeneacetamide; 1-acetyl-3-(2-phenylbutyryl)urea; N-(α-ethylphenylacetyl)-N′-acetylurea; Crampol (Dainippon).
C13H16N2O3; mol wt 248.28.
C 62.89%, H 6.50%, N 11.28%, O 19.33%.

Description and references

Synthesis: Umemoto et al., Yakugaku Zasshi 83, 753 (1963), C.A. 59, 13849d (1963); Takamatsu et al., US 3110728 (1963 to Dainippon). Pharmacology and toxicology: Nakamura et al., Arzneim.-Forsch. 18, 524 (1968).

Chemical structure

Properties

Crystals from dil alcohol, mp 100-101°. LD50 orally in mice: 4.73 mMole/kg (1.17 g/kg) (Nakamura).

Therapeutic Category

Anticonvulsant.

Keywords

Anticonvulsant