Description and references

Antitumor antibiotic complex of the anthracycline group, produced by Streptomyces galilaeus. Thirteen yellow and seven red-colored components have been identified. Isoln of the major components, aclacinomycins A and B: H. Umezawa et al., DE 3532568; eidem, US 3988315 (1974, 1976 both to Microbiochem. Res. Found.). See also: T. Oki et al., J. Antibiot. 28, 830 (1975). Structure, taxonomy, production, properties: eidem, ibid. 32, 791, 801 (1979). The aglycone portion of aclacinomycin A is known as aklavinone. Isoln of aklavinone: J. J. Gordon et al., Tetrahedron Lett. 8, 28 (1960). Synthesis of racemic aklavinone: B. A. Pearlman et al., J. Am. Chem. Soc. 103, 4248 (1981); P. A. Confalone, G. Pizzolato, ibid. 4251; R. K. Boeckman, F. W. Sum, ibid. 104, 4604 (1982). Synthesis of optically active aklavinone: A. S. Kende, J. P. Rizzi, ibid. 103, 4247 (1981); J. M. McNamara, Y. Kishi, ibid. 104, 7371 (1982). In vitro metabolism of aclacinomycins: T. Komiyama et al., Gann 70, 395 (1979), C.A. 92, 15143x (1980). HPLC determn of aclacinomycin A and its metabolites: T. Ogasawara et al., J. Antibiot. 34, 47, 52 (1981). Pharmacokinetics: M. J. Egorin et al., Cancer Chemother. Pharmacol. 8, 41 (1982). Series of articles on absorption, excretion, distribution and general pharmacology: Jpn. J. Antibiot. 33, 169-213 (1980), C.A. 93, 19316, 125326, 125649, 142986 (1980). Immunological study: M. Ishizuka et al., J. Antibiot. 34, 331 (1981). Clinical studies: R. Maral, Drugs Exp. Clin. Res. 9, 375 (1983); R. P. Warrell, Jr., S. J. Kempin, Am. J. Clin. Oncol. 6, 81 (1983); A. Y. Bedikian et al., ibid. 187 (1983). Review of pharmacology of aclacinomycin A: T. Oki, Anthracyclines [Proc. Workshop], S. T. Crooke, S. D. Reich, Eds. (Academic Press, New York, 1980) pp 323-342, C.A. 93, 160778h (1980).

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