114. Aclatonium Napadisilate

Nomenclature

CAS number: 55077-30-0
2-[2-(Acetyloxy)-1-oxopropoxy]-N,N,N-trimethylethanaminium 1,5-naphthalenedisulfonate (2:1); 1,5-naphthalenedisulfonic acid bis [2-[2-(acetyloxy)-1-oxopropoxy]-N,N,N-trimethylethanaminium]ion (2); acetyllactoylcholine 1,5-naphthalenedisulfonate; choline 1,5-naphthalenedisulfonate (2:1), dilactate, diacetate; TM-723; Abovis (Toyama).
C30H46N2O14S2; mol wt 722.82.
C 49.85%, H 6.41%, N 3.88%, O 30.99%, S 8.87%.

Description and references

Spasmolytic agent related structurally to acetylcholine chloride, q.v. Prepn: K. Miura et al., DE 2425983; eidem, US 3903137 (1973, 1975 both to Toyama). Synthesis and smooth muscle activity: eidem, Yakugaku Zasshi 99, 1245 (1979), C.A. 92, 146197r (1980). Toxicity study: A. Takai et al., Oyo Yakuri 19, 93 (1980), C.A. 93, 613367 (1980). Series of articles on metabolism, pharmacology, toxicity studies: Oyo Yakuri 18, 695-942 (1979), C.A. 92, 191015r, 191281z, 191282a, 208995k-7n (1980).

Chemical structure

Properties

Crystals, mp 189-191°. LD50 in mice: 15 g/kg orally, 826 mg/kg s.c. (Miura); in dogs: >10 g/kg orally (Takai).

Therapeutic Category

Cholinergic.

Keywords

Cholinergic