132. Actaplanins
Nomenclature
A-4696; Kamoran (Lilly).Description and references
Complex of glycopeptide antibiotics produced by Actinoplanes missouriensis. Six actaplanins (A, B1, B2, B3, C1, G) have been isolated and characterized as having a central peptide core with the amino sugar ristosamine and up to four neutral sugars attached. Isoln: R. L. Hamill et al., DE 2209018 (1972 to Lilly), C.A. 77, 138338n (1972); A. P. Raun, US 3816618; R. L. Hamill et al., US 4115552 (1974, 1978 to Lilly). Chemical characterization: M. Debono et al., J. Antibiot. 37, 85 (1984). 1H NMR studies and structures: A. H. Hunt et al., J. Org. Chem. 49, 635 (1984); eidem, ibid. 641. Growth promotant activity: C. Tsaltos et al., Bull. Hellenic Vet. Med. Soc. 33, 139 (1982). Use to increase milk production in ruminants: C. C. Scheifinger, EP 63491; idem, US 4430328 (1982, 1984 to Eli Lilly). Determn in milk: K. H. Hahne et al., Milchwissenschaft 39, 473 (1984).
