170. Adrafinil

Nomenclature

CAS number: 63547-13-7
2-[(Diphenylmethyl)sulfinyl]-N-hydroxyacetamide; 2-(benzhydrylsulfinyl)acetohydroxamic acid; CRL-40028; Olmifon (Lafon).
C15H15NO3S; mol wt 289.35.
C 62.26%, H 5.23%, N 4.84%, O 16.59%, S 11.08%.

Description and references

α-Adrenergic agonist. Prepn, pharmacology: L. Lafon, BE 846880; US 4066686 (1977, 1978 both to Lafon). Mode of action: J. Duteil et al., Eur. J. Pharmacol. 59, 121 (1979); C. Rozé et al., Arch. Int. Pharmacodyn. Ther. 265, 119 (1983). Psychopharmacology in mice: F. A. Rambert et al., J. Pharmacol. 17, 37 (1986).

Chemical structure

Properties

Crystals from ethyl acetate-isopropyl alcohol, mp 159-160°. Soly in water <1 g/l. LD50 in mice (mg/kg): <2048 i.p.; 1950 gastric admin (Lafon).

Therapeutic Category

Treatment of depression.

Keywords

α-Adrenergic Agonist; Antidepressant