173. Adrenoglomerulotropin

Nomenclature

CAS number: 1210-56-6
2,3,4,9-Tetrahydro-6-methoxy-1-methyl-1H-pyrido[3,4-b]indole; aldosterone-stimulating hormone; ASH; 1-methyl-6-methoxy-1,2,3,4-tetrahydro-2-carboline.
C13H16N2O; mol wt 216.28.
C 72.19%, H 7.46%, N 12.95%, O 7.40%.

Description and references

Found in extracts of pineal gland tissue: Farrell, Circulation 21, 1009 (1960); Farrell, McIsaac, Arch. Biochem. Biophys. 94, 543 (1961). Synthesis from 5-methoxytryptamine and acetaldehyde: McIsaac, Biochim. Biophys. Acta 52, 607 (1961); Meek et al., Chem. Ind. (London) 1964, 622.

Chemical structure

Properties

Crystals, mp 150-151°. uv max (ethanol): 225, 280 nm (log ε 4.34, 3.86); (0.1N HCl): 220, 273 nm (log ε 4.40, 3.86).