197. Ajugarins
Description and references
Diterpenes isolated from the leaves of Ajuga remota (Labiatae). Five different ajugarins have been isolated and identified; of these ajugarins I-III possess antifeedant activity against the African army worm, ajugarin-IV has insecticidal activity, ajugarin V is inactive. Isoln and structure of ajugarins I-III: I. Kubo et al., Chem. Commun. 1976, 949; of ajugarin IV: eidem, ibid. 1982, 618; of ajugarin V: eidem, Chem. Lett. 1983, 223. See also: JP Kokai 82 48979 (1982 to Otsuka). X-ray crystal structure of 12-bromoajugarin-I and absolute configuration: I. Kubo et al., Chem. Commun. 1980, 897; 13C-NMR shift data: J. M. Luteijn et al., Org. Magn. Reson. 19, 95 (1982). Synthetic approaches: D. J. Goldsmith et al., J. Org. Chem. 43, 3182 (1978); J. M. Luteijn, Ae. de Groot, Tetrahedron Lett. 1981, 789. Total synthesis of ajugarin-I: S. V. Ley et al., Chem. Commun. 1983, 503.
