219. Alclofenac

Nomenclature

CAS number: 22131-79-9
3-Chloro-4-(2-propenyloxy)benzeneacetic acid; [4-(allyloxy)-3-chlorophenyl]acetic acid; W-7320; Allopydin (Chugai); Mervan (Continental Pharma).
C11H11ClO3; mol wt 226.66.
C 58.29%, H 4.89%, Cl 15.64%, O 21.18%.

Description and references

Prepn: N. P. Buu-Hoi et al., BE 704368 (1968 to Madan). Pharmacology: eidem, Naturwissenschaften 56, 330 (1969). Series of articles on pharmacology, toxicology and metabolism: Arzneim.-Forsch. 20, 610-636 (1970). Toxicity data: G. Lambelin et al., ibid. 618. HPLC determn in equine plasma and urine: F. T. Delbeke et al., J. Chromatogr. 621, 209 (1993). Clinical studies: F. Lambotte, ibid. 569; Van Hoek, Curr. Ther. Res. 12, 551 (1970).

Chemical structure

Properties

Prisms from cyclohexane, mp 92-93°. LD50 in mice, rats (mg/kg): 1100, 1050 orally; 600, 630 s.c.; 555, 530 i.p. (Lambelin).

Therapeutic Category

Analgesic; antipyretic; anti-inflammatory.