221. Alcuronium

Nomenclature

CAS number: 23214-96-2
4,4′-Didemethyl-4,4′-di-2-propenyltoxiferine I; N,N′-diallylnortoxiferinium; diallylbis(nortoxiferine); diallylnortoxiferine; diallyltoxiferine.
[C44H50N4O2]2+.

Description and references

Prepn of dichloride and diiodide: Boller et al., US 3080373 (1963 to Hoffmann-La Roche).

Chemical structure

Derivative

Dichloride.

Nomenclature

CAS number: 15180-03-7
N,N′-Diallylnortoxiferinium dichloride; Ro-4-3816; Alloferin (Roche).
C44H50Cl2N4O2; mol wt 737.80.
C 71.63%, H 6.83%, Cl 9.61%, N 7.59%, O 4.34%.

Properties

Crystals from methanol or ethanol. Compd contains 5 moles of water of crystn after equilibration in air; [α]D22 348° (methanol); uv max (methanol): 292 nm (ε 43000).

Derivative

Diiodide.
C44H50I2N4O2; mol wt 920.70.
C 57.40%, H 5.47%, I 27.57%, N 6.09%, O 3.48%.

Properties

Solid. uv max (methanol): 291 nm (ε 39900).

Therapeutic Category

Neuromuscular blocking agent.

Therapeutic Category (Veterinary)

Neuromuscular blocking agent.

Keywords

Neuromuscular Blocking Agent; Nondepolarizing Agents