232. Alexidine

Nomenclature

CAS number: 22573-93-9
N,N″-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide; 1,1′-hexamethylenebis[5-(2-ethylhexyl)biguanide]; Win-21904; Sterwin 904; Bisguadine (Sterwin).
C26H56N10; mol wt 508.79.
C 61.38%, H 11.09%, N 27.53%.

Description and references

Prepn from 1,1′-hexamethylenebis(3-cyanoguanide) and 2-ethylhexylamine hydrochloride: FR 1463818 (1965 to Sterling Drug). Evaluation as antimicrobial agent: McNamara et al., J. Soc. Cosmet. Chem. 16, 499 (1965).

Chemical structure

Derivative

Dihydrochloride.

Properties

Crystals from methanol + ether, mp 220.6-223.4°.

Therapeutic Category

Antibacterial.

Keywords

Antiseptic/Disinfectant; Guanidines