233. Alfadolone Acetate

Nomenclature

CAS number: 23930-37-2
(3α,5α)-21-(Acetyloxy)-3-hydroxypregnane-11,20-dione; 3α,21-dihydroxy-5α-pregnane-11,20-dione 21-acetate; 21-acetoxy-3α-hydroxy-5α-pregnane-11,20-dione; alphadolone acetate; GR-2/1574.
C23H34O5; mol wt 390.51.
C 70.74%, H 8.78%, O 20.49%.

Description and references

Prepn: Brown, Kirk, J. Chem. Soc. C 1969, 1653; Davis et al., DE 2030402 and ZA 7003861 (both 1971 to Glaxo), C.A. 75, 20793n, 64114w (1971).

Chemical structure

Properties

Crystals from acetone-hexane, mp 175-177°. [α]D26 +97° (c = 1.02 in chloroform).

Derivative

Mixture with alfaxalone see Alfaxalone.

Therapeutic Category

Combination with alfaxalone as anesthetic (intravenous).

Therapeutic Category (Veterinary)

Combination with alfaxalone as anesthetic (intravenous).

Keywords

Anesthetic (Intravenous)