250. Alizapride

Nomenclature

CAS number: 59338-93-1
6-Methoxy-N-[[1-(2-propenyl)-2-pyrrolidinyl]methyl]-1H-benzotriazole-5-carboxamide; N-[(1-allyl-2-pyrrolidinyl)methyl]-6-methoxy-1H-benzotriazole-5-carboxamide.
C16H21N5O2; mol wt 315.37.
C 60.94%, H 6.71%, N 22.21%, O 10.15%.

Description and references

Prepn: BE 825605; G. Bulteau et al., US 4039672 (1975, 1977 both to Soc. d'Etudes Sci. Ind. de l'Ile-de-France). Series of articles on pharmacology and clinical studies in chemotherapy induced emesis: Sem. Hop. 58, 323-374 (1982).

Chemical structure

Properties

Cryst from acetone, mp 139°. LD50 i.v. in mice (5 days): 92.7 mg/kg (Bulteau).

Derivative

Hydrochloride.

Nomenclature

CAS number: 59338-87-3
Nausilen (Baldacci); Plitican (Synthelabo); Vergentan (Synthelabo).
C16H21N5O2.HCl; mol wt 351.83.
C 54.62%, H 6.30%, N 19.91%, O 9.09%, Cl 10.08%.

Properties

Cryst from methanol/methyl ethyl ketone, mp 206-208°.

Therapeutic Category

Antiemetic.

Keywords

Antiemetic