12-00024. Aceglatone [Archived]

Nomenclature

CAS number: 642-83-1
d-Glucaric acid di-γ-lactone diacetate; 2,5-di-O-acetyl-d-glucaro-1,4:6,3-dilactone; 2,5-di-O-acetyl-d-glucosaccharo-1,4:6,3-dilactone; Glucaron (Chugai).
C10H10O8; mol wt 258.18.
C 46.52%, H 3.90%, O 49.58%.

Description and references

Prepn and structure: Hirasaka, Umemoto, Chem. Pharm. Bull. 13, 325 (1965), C.A. 63, 3024h (1965); Ishidate et al., JP 67 14956 (1967 to Tokyo Biochem. Res. Com.), C.A. 68, 78558m (1968). Pharmacological studies: Iida et al., Jpn. J. Pharmacol. 15, 88 (1965), C.A. 63, 5961g (1965).

Chemical structure

Properties

White, odorless and tasteless crystalline powder, mp 185-186° (Hirasaka). Sol in dimethylformamide, sparingly sol in acetone, slightly sol in dioxane, methanol and ethanol. Practically insol in water.

Therapeutic Category

Antineoplastic.

Status

This monograph has been retired and is no longer subject to revision or update.