13-00004. Abecarnil [Archived]
Nomenclature
CAS number: 111841-85-1
4-(Methoxymethyl)-6-(phenylmethoxy)-9H-pyrido[3,4-b]indole-3-carboxylic acid 1-methylethyl ester; isopropyl 6-(benzyloxy)-4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylate; isopropyl 6-(benzyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylate; ZK-112119. C24H24N2O4; mol wt 404.46.
C 71.27%, H 5.98%, N 6.93%, O 15.82%.
Description and references
Benzodiazepine receptor agonist. Prepn: H. Biere et al., DE 3609699 (1987 to Schering AG), C.A. 108, 21872z (1988). Pharmacology and receptor binding studies: D. N. Stephens et al., J. Pharmacol. Exp. Ther. 253, 334 (1990). Determn in biological samples: W. Krause et al., J. Pharm. Sci. 78, 622 (1989). Clinical pharmacokinetics: W. Krause et al., Xenobiotica 21, 763 (1991). Clinical trial in anxiety: J. C. Ballenger et al., Adv. Biochem. Psychopharmacol. 47, 431 (1992). Series of articles on pharmacology, tolerance and clinical evaluation: Psychopharmacol. Ser. 11, 50-147 (1993).
Properties
Crystals from ethyl acetate, mp 150-151°.Therapeutic Category
Anxiolytic.
Keywords
Anxiolytic
Status
This monograph has been retired and is no longer subject to revision or update.