13-00192. Ahistan [Archived]

Nomenclature

CAS number: 518-61-6
10-(Dimethylamino)acetyl-10H-phenothiazine; 10-(N,N-dimethylglycyl)phenothiazine; dacemazine.
C16H16N2OS; mol wt 284.38.
C 67.58%, H 5.67%, N 9.85%, O 5.63%, S 11.28%.

Description and references

Prepd from phenothiazine and chloroacetyl chloride, followed by treatment with dimethylamine: Cusic, US 2694705 (1954 to Searle).

Chemical structure

Properties

Crystals, mp 144-145°.

Derivative

Hydrochloride.
C16H16N2OS.HCl; mol wt 320.84.
C 59.90%, H 5.34%, N 8.73%, O 4.99%, S 9.99%, Cl 11.05%.

Properties

Crystals, mp 230-231°.

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Tricyclics; Phenothiazines

Status

This monograph has been retired and is no longer subject to revision or update.