318. Althiazide

Nomenclature

CAS number: 5588-16-9
6-Chloro-3,4-dihydro-3-[(2-propenylthio)methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-[(allylthio)methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-allylthiomethyl-6-chloro-7-sulfamoyl-3,4-dihydrobenzothiadiazine 1,1-dioxide; 6-chloro-3,4-dihydro-7-sulfamoyl-3-(2-thiapent-4-enyl)-2H-1,2,4-benzothiadiazine 1,1-dioxide; altizide; P-1779.
C11H14ClN3O4S3; mol wt 383.89.
C 34.42%, H 3.68%, Cl 9.24%, N 10.95%, O 16.67%, S 25.06%.

Description and references

Prepn: GB 902658; W. M. McLamore, G. D. Laubach, US 3111517 (1962, 1963 both to Pfizer). HPLC determn in tablets: F. DeCroo et al., J. Chromatogr. 329, 422 (1985). Clinical evaluation in hypertension: G. Simon et al., Curr. Ther. Res. 46, 44 (1989).

Chemical structure

Properties

Solid, mp 206-207°.
Combination with spironolactone, Aldactazine.

Therapeutic Category

Diuretic; antihypertensive.

Keywords

Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs