371. Alverine

Nomenclature

CAS number: 150-59-4
N-Ethyl-N-(3-phenylpropyl)benzenepropanamine; N-ethyl-3,3′-diphenyldipropylamine; bis(γ-phenylpropyl)ethylamine; di(phenylpropyl)ethylamine.
C20H27N; mol wt 281.44.
C 85.35%, H 9.67%, N 4.98%.

Description and references

Prepn: Külz et al., Ber. 72, 2165 (1939); Stühner, Elbrchter, Arch. Pharm. 287, 139 (1954). Physical properties: E. F. Salim, W. R. Ebert, J. Pharm. Sci. 56, 1162 (1967). Clinical trial in irritable bowel syndrome: G. J. Tudor, Br. J. Clin. Pract. 40, 276 (1985).

Chemical structure

Properties

Liquid, bp0.3 165-168°; bp13 210-215°.

Derivative

Citrate.

Nomenclature

CAS number: 5560-59-8
Spasmaverine (Bellon); Spasmonal (Norgine).
C20H27N.C6H8O7; mol wt 473.56.
C 65.94%, H 7.45%, N 2.96%, O 23.65%.

Properties

White to off-white powder having a sweet odor and slightly bitter taste, mp 100-102°. Slightly sol in water, chloroform; sparingly sol in alcohol; very slightly sol in ether.

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic