379. Ambenonium Chloride

Nomenclature

CAS number: 115-79-7
N,N′-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethylbenzenemethanaminium] chloride (1:2); [oxalylbis(iminoethylene)]bis[(o-chlorobenzyl)diethylammonium chloride]; N,N′-bis[2-diethylaminoethyl]oxamide bis[2-chlorobenzyl chloride]; Win-8077; Mytelase (Sanofi-Aventis).
C28H42Cl4N4O2; mol wt 608.47.
C 55.27%, H 6.96%, Cl 23.31%, N 9.21%, O 5.26%.

Description and references

Reversible acetylcholinesterase inhibitor. Prepn: F. K. Kirchner, DE 1024517 (1958 to Sterling Drug), C.A. 54, 18366g (1960). Cholinesterase inhibition kinetics: A. S. Hodge et al., Mol. Pharmacol. 41, 937 (1992) PubMed. HPLC determn in serum: K. Ohtsubo et al., J. Chromatogr. 496, 397 (1989) DOI PubMed. Clinical pharmacokinetics in patients with myasthenia gravis: C. Tharasse-Bloch et al., Eur. J. Drug Metab. Pharmacokinet. 16, 299 (1991) PubMed.

Chemical structure

Properties

Crystals, mp 196-199°. Freely soluble in water.

Therapeutic Category

In treatment of myasthenia gravis.

Keywords

Cholinesterase Inhibitor; Antimyasthenic