388. Amcinonide

Nomenclature

CAS number: 51022-69-6
(11β,16α)-21-(Acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxypregna-1,4-diene-3,20-dione; 9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclopentanone 21-acetate; CL-34699; Amciderm (Hermal); Cyclocort (Fujisawa); Penticort (Lederle).
C28H35FO7; mol wt 502.57.
C 66.92%, H 7.02%, F 3.78%, O 22.28%.

Description and references

Prepn: W. Shultz et al., DE 2437847 (1975 to Am. Cyanamid), C.A. 83, 10608g (1975). Bioavailability study: R. Woodford, J. M. Haigh, Curr. Ther. Res. 26, 301 (1979). Therapeutic use in eczematoid conditions: G. L. Rocha et al., ibid. 19, 538 (1976); E. W. Rosenberg, Cutis 24, 642 (1979).

Chemical structure

Therapeutic Category

Glucocorticoid.

Keywords

Glucocorticoid