Am; at. no. 95; valences 3, 4, 5, 6. Man-made radioactive element. No stable nuclides; known isotopes (mass numbers): 234, 237-247. Longest-lived known isotope 243 (T 7.38 × 103 years, rel. at. mass 243.0614, α-emitter). First isotope prepared: 241Am (T 432.7 years, α and γ-emitter, rel. at. mass 241.0568); prepd in 1944 by G. T. Seaborg et al. in The Transuranium Elements, G.T. Seaborg et al., Eds., (McGraw-Hill, New York, 1949) p 1525-1553; eidem, Phys. Rev. 78, 472 (1950). Isoln: Armstrong et al., AIChE J. 3, 286 (1957); Coleman, J. Inorg. Nucl. Chem. 3, 327 (1957). Prepn of metal: E. F. Westrum, Jr., L. Eyring, J. Am. Chem. Soc. 73, 3396 (1951); Cunningham, Lohr, ibid. 2026. Superconducting properties: J. L. Smith, R. G. Haire, Science 200, 535 (1978). Clinical application in bone mineral determn: E. G. De Puey et al., J. Nucl. Med. 16, 891 (1975); in cancer radiotherapy: R. Nath et al., Int. J. Radiat. Oncol. Biol. Phys. 14, 969 (1988). Reviews: C. Keller, The Chemistry of the Transuranium Elements (Verlag Chemie, Weinheim, English Ed., 1971) pp 485-527; Comprehensive Inorganic Chemistry vol. 5, J. C. Bailar, Jr. et al., Eds. (Pergamon Press, Oxford, 1973) passim; Handb. Exp. Pharmakol. 36, 689-940 (1973); W. W. Schulz, R. A. Penneman in The Chemistry of the Actinide Elements vol. 2, J. J. Katz et al., Eds. (Chapman and Hall, New York, 1986) pp 887-961. See also metabolism study of internal contamination of 241Am in man: N. Cohen et al., Science 206, 64 (1979). Review of toxicology and human exposure: Toxicological Profile for Americium (PB2004-104396, 2004) 333 pp.
241Am as diagnostic aid (bone mineral analyzer); as antineoplastic (radiation source).
Americium 241Am: Antineoplastic (Radiation Source); Diagnostic Aid