410. Aminitrozole

Nomenclature

CAS number: 140-40-9
N-(5-Nitro-2-thiazolyl)acetamide; 2-acetamido-5-nitrothiazole; 2-acetylamino-5-nitrothiazole; acinitrazole; nithiamide; Tritheon (Ortho); Trichorad; Enheptin-A (Am. Cyanamid).
C5H5N3O3S; mol wt 187.18.
C 32.08%, H 2.69%, N 22.45%, O 25.64%, S 17.13%.

Description and references

Prepd by nitration of 2-acetamidothiazole: Ganapathi, Venkataraman, Proc. Indian Acad. Sci. 22A, 343 (1945); Bellavita, Ann. Chim. Appl. 38, 449 (1948); Hurd, Wehrmeister, J. Am. Chem. Soc. 71, 4007 (1949); Yamamoto, J. Pharm. Soc. Jpn. 72, 1017 (1952). As an antihistomonad: Waletzky, Marson, US 2531756 (1950 to Am. Cyanamid).

Chemical structure

Properties

Needles from alc, elongated plates from acetic acid. mp 264-265°. The commercial product may be yellow. Sol in aq solns of NaOH and NH3 with deep orange color.

Therapeutic Category

Antiprotozoal (Trichomonas).

Therapeutic Category (Veterinary)

Antihistomonad for turkeys.

Keywords

Antiprotozoal (Trichomonas)