451. Aminometradine

Nomenclature

CAS number: 642-44-4
6-Amino-3-ethyl-1-(2-propen-1-yl)-2,4(1H,3H)-pyrimidinedione; 1-allyl-6-amino-3-ethyluracil; 1-allyl-6-amino-3-ethyl-2,4(1H,3H)-pyrimidinedione; 1-allyl-3-ethyl-6-amino-1,2,3,4-tetrahydro-2,4-pyrimidinedione; aminometramide; Mictine (Searle); Mincard (Searle).
C9H13N3O2; mol wt 195.22.
C 55.37%, H 6.71%, N 21.52%, O 16.39%.

Description and references

Prepn: Papesch, Schroeder, US 2650922 (1953 to Searle). Clinical trial in congestive heart failure: M. M. Platts, T. Hanley, Br. Med. J. 1, 1078 (1956) DOI PubMed.

Chemical structure

Properties

Monohydrate, crystals from water, mp 75-115°. When anhydrous, mp 143-144°.

Therapeutic Category

Diuretic.

Keywords

Diuretic; Uracils