625. Anastrozole

Nomenclature

CAS number: 120511-73-1
α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile; 2,2′-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile); ZD-1033; ICI-D-1033; Arimidex (AstraZeneca).
C17H19N5; mol wt 293.37.
C 69.60%, H 6.53%, N 23.87%.

Description and references

Aromatase inhibitor. Prepn: P. N. Edwards, M. S. Large, EP 296749; eidem, US 4935437 (1989, 1990 both to ICI). Reviews of pharmacology, clinical pharmacokinetics: P. V. Plourde et al., Breast Cancer Res. Treat. 30, 103-111 (1994); idem et al., J. Steroid Biochem. Mol. Biol. 53, 175-179 (1995). Clinical trial in advanced breast cancer: A. U. Buzdar et al., Cancer 79, 730 (1997).

Chemical structure

Properties

Crystals from ethyl acetate/cyclohexane, mp 81-82°.

Therapeutic Category

Antineoplastic.

Keywords

Antineoplastic (Hormonal); Aromatase Inhibitors; Aromatase Inhibitors