700. Antimony Potassium Tartrate

Nomenclature

CAS number: 28300-74-5
Bis[μ-[2,3-di(hydroxy-κO)butanedioato(4)-κO1:κO4]]diantimonate(2) potassium hydrate (1:2:3) stereoisomer; tartar emetic; tartrated antimony; tartarized antimony; potassium antimonyltartrate.
C8H4K2O12Sb2.3H2O; mol wt 667.87.
C 14.39%, H 1.51%, K 11.71%, O 35.93%, Sb 36.46%.

Description and references

Manuf from potassium bitartrate and metallic antimony in the presence of HNO3 or solid antimony oxide: Davies, US 2335585 (1943 to Am. Cream Tartar); US 2391297 (1945 to Stauffer Chem.). Structural studies: P. Pfeiffer, E. Schmitz, Pharmazie 4, 451 (1949); E. Chinoporos, N. Papathanasopoulos, J. Phys. Chem. 65, 1643 (1961); D. Grdenic, B. Kamenar, Acta Crystallogr. 19, 197 (1965); R. Iyer et al., J. Inorg. Nucl. Chem. 34, 3351 (1972). Toxicity: N. Ercoli, Proc. Soc. Exp. Biol. Med. 129, 284 (1968). Anthelmintic activity: Z. Farid et al., Trans. R. Soc. Trop. Med. Hyg. 66, 119 (1972); R. R. C. New et al., Nature 272, 56 (1978). Oxidimetric determn: Y. A. Gawargious et al., Pharmazie 41, 59 (1980).

Chemical structure

Properties

Transparent crystals (effloresce on exposure to air) or powder. Sweetish, metallic taste. d 2.6. [α]D20 +140.69° (c = 2 in water), +139.25° (c = 2 in glycerol). Poisonous. One gram dissolves in 12 ml water, 3 ml boiling water, 15 ml glycerol. Insol in alcohol. The aq soln is slightly acid. LD50 in mice (mg/kg): 55 s.c.; 65 i.v. (Ercoli). Incompat. Mineral acids, tannic acid, gallic acids, alkali hydroxides and carbonates, lead and silver salts, mercury bichloride, lime water, albumin, soap.

Use

As mordant in the textile and leather industry.

Therapeutic Category

Anthelmintic (Schistosoma).

Therapeutic Category (Veterinary)

Has been used as a parasiticide (gastrointestinal and blood parasites); as an expectorant, and as a ruminatoric.

Keywords

Anthelmintic (Schistosoma)