717. Antipyrine Salicylate

Nomenclature

CAS number: 520-07-0
2-Hydroxybenzoic acid compd with 1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one (1:1); Phenazone salicylate; Saliphenazon; Salazolon; Salipyrazolon; Salipyrine.
C18H18N2O4; mol wt 326.35.
C 66.25%, H 5.56%, N 8.58%, O 19.61%.

Description and references

Prepd by fusing antipyrine and salicylic acid: Hagers Handb. Pharm. Praxis Vol. 6, (Springer Verlag, Berlin, 1977) p 574.

Chemical structure

Properties

Slightly sweet, cryst powder. mp 91-92°. One gram dissolves in 200 ml water, 40 ml boil. water; freely sol in alc, chloroform, sparingly in ether.

Therapeutic Category

Analgesic.

Therapeutic Category (Veterinary)

Has been used as an antipyretic, analgesic in dogs.