726. Apazone

Nomenclature

CAS number: 13539-59-8
5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione; 3-dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine; azapropazone; AHR-3018; MI-85.
C16H20N4O2; mol wt 300.36.
C 63.98%, H 6.71%, N 18.65%, O 10.65%.

Description and references

Prepn: FR 1440629; I. Molnar et al., US 3349088 (1966, 1967, both to Siegfried); Mixich, Helv. Chim. Acta 51, 532 (1968). Pharmacological and toxicological studies: Jahn, Adrian, Arzneim.-Forsch. 19, 36 (1969). Metabolism: Mixich, Helv. Chim. Acta 55, 1031 (1972). HPLC determn in plasma and urine: B. J. Kline et al., Arzneim.-Forsch. 33, 504 (1983).

Chemical structure

Properties

mp 228°.

Derivative

Dihydrate.

Nomenclature

CAS number: 22304-30-9
MI-85Di; Prolixan (Siegfried); Rheumox (Goldshield).

Properties

Almost colorless crystals, mp 247-248°.

Therapeutic Category

Anti-inflammatory.