865. Atosiban

Nomenclature

CAS number: 90779-69-4
O-Ethyl-N-(3-mercapto-1-oxopropyl)-d-tyrosyl-l-isoleucyl-l-threonyl-l-asparaginyl-l-cysteinyl-l-prolyl-l-ornithylglycinamide cyclic (1→5)-disulfide; 1-(3-mercaptopropanoic acid)-2-(O-ethyl-d-tyrosine)-4-l-threonine-8-l-ornithineoxytocin; 1-(3-mercaptopropionic acid)-2-[3-(p-ethoxyphenyl)-d-alanine]-4-l-threonine-8-l-ornithineoxytocin; 1-deamino-2-d-tyr-(OEt)-4-thr-8-orn-oxytocin; antocin; dTVT; ORF-22164; F-314; RWJ-22164; CAP-440; Tractocile (Ferring).
C43H67N11O12S2; mol wt 994.19.
C 51.95%, H 6.79%, N 15.50%, O 19.31%, S 6.45%.

Description and references

Oxytocin antagonist. Prepn: P. O. R. Melin, J. A. Trojnar, EP 112809; eidem, US 4504469 (1984, 1985 both to Ferring). Mechanism of action: A. Lopez Bernal et al., Br. J. Obstet. Gynaecol. 96, 1108 (1989). Effect on in vitro contractility of myometrium: V. A. Kinsler et al., ibid. 103, 373 (1996). Clinical pharmacokinetics: T. M. Goodwin et al., Am. J. Obstet. Gynecol. 173, 913 (1995). Clinical trial: T. M. Goodwin et al., ibid. 170, 474 (1994).

Chemical structure

Therapeutic Category

Tocolytic.

Keywords

Tocolytic