897. Azanidazole

Nomenclature

CAS number: 62973-76-6
(E)-4-[2-(1-Methyl-5-nitro-1H-imidazol-2-yl)ethenyl]-2-pyrimidinamine; (E)-2-amino-4-[2-(1-methyl-5-nitroimidazol-2-yl)vinyl]pyrimidine; nitromidine; F-4; Triclose (ICT).
C10H10N6O2; mol wt 246.23.
C 48.78%, H 4.09%, N 34.13%, O 13.00%.

Description and references

Prepn and use: A. Garzia, DE 2358483; eidem, US 3882105; US 3969520 (1974, 1975, 1976 all to Chemoterapico). Toxicological and teratological studies: R. Tammiso et al., Arzneim.-Forsch. 28, 2251 (1978).

Chemical structure

Properties

Bright yellow odorless powder, mp 232-235°. Sol in DMF, DMSO, mineral oils and acids. Slightly sol in dioxane and acetone. LD50 in mice, rats (mg/kg): 5100, 7600 orally; 590, 860 i.p. (Tammiso).

Therapeutic Category

Antiprotozoal (Trichomonas).

Keywords

Antiprotozoal (Trichomonas)