901. Azatadine

Nomenclature

CAS number: 3964-81-6
6,11-Dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 4-aza-5-(N-methyl-4-piperidinylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene.
C20H22N2; mol wt 290.40.
C 82.72%, H 7.64%, N 9.65%.

Description and references

Prepn: F. J. Villani, BE 647043 (1964 to Scherico); idem, US 3326924 (1967 to Schering); idem et al., J. Med. Chem. 15, 750 (1972). Pharmacology: S. Tozzi et al., Agents Actions 4, 264 (1974). Toxicity studies: H. Tanaka et al., Jitchuken Zenrinsho Kenkyuho 1, 173 (1975), C.A. 84, 25951h (1976). Clinical evaluation in allergic rhinitis: J. D. Wilson et al., N. Z. Med. J. 94, 79 (1981).

Chemical structure

Properties

Crystals from isopropyl ether, mp 124-126°.

Derivative

Dimaleate.

Nomenclature

CAS number: 3978-86-7
Sch-10649; Bonamid (Heilmittelwerke); Idulian (Schering); Optimine (Schering); Zadine (Schering).
C20H22N2.2C4H4O4; mol wt 522.55.
C 64.36%, H 5.79%, N 5.36%, O 24.49%.

Properties

Crystals from ethyl acetate-methanol, mp 152-154°.

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Tricyclics; Other Tricyclics