922. Azosemide

Nomenclature

CAS number: 27589-33-9
2-Chloro-5-(1H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]benzenesulfonamide; 2-chloro-5-(2H-tetrazol-5-yl)-N4-2-thenylsulfanilamide; 5-(4′-chloro-2′-thenylamino-5′-sulfamoylphenyl)tetrazole; Ple-1053; Diart (Boehringer, Mann.); Luret (Sanofi Winthrop).
C12H11ClN6O2S2; mol wt 370.84.
C 38.87%, H 2.99%, Cl 9.56%, N 22.66%, O 8.63%, S 17.29%.

Description and references

Prepn: A. Popelak et al., DE 1815922; eidem, US 3665002 (1968, 1972 both to Boehringer, Mann.). Separation and analysis in blood and urine by HPLC: R. Seiwell, C. Brater, J. Chromatogr. 182, 257 (1980). Sites of action: C. Brater, Clin. Pharmacol. Ther. 25, 428 (1979). Clinical and pharmacological studies: F. Krueck et al., Eur. J. Clin. Pharmacol. 14, 153 (1978). Diuretic effect in animals: J. Greven, O. Heidenreich, Arzneim.-Forsch. 31, 346, 350 (1981).

Chemical structure

Properties

Crystals, mp 218-221°.

Therapeutic Category

Diuretic.

Keywords

Diuretic; Sulfonamide Derivatives