944. Balofloxacin

Nomenclature

CAS number: 127294-70-6
1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-(methylamino)-1-piperidinyl]-4-oxo-3-quinolinecarboxylic acid; Q-35; Baloxin (Chugai).
C20H24FN3O4; mol wt 389.42.
C 61.69%, H 6.21%, F 4.88%, N 10.79%, O 16.43%.

Description and references

Fluorinated quinolone antibacterial. Prepn: H. Nagano et al., EP 342675; eidem, US 5051509 (1989, 1991 both to Chugai). Photostability: K. Marutani et al., Antimicrob. Agents Chemother. 37, 2217 (1993). Comparative antibacterial spectrum: H. Iwasaki et al., Chemotherapy (Basel) 41, 100 (1995). Pharmacokinetics: T. Nakagawa et al., Arzneim.-Forsch. 45, 719 (1995). HPLC determn in biological fluids: T. Nakagawa et al., ibid. 716. Clinical evaluation in respiratory tract infection: O. Kunii, F. Matsumoto, Proc. 18th Int. Congr. Chemother., Stockholm 1993, 22-23; in urinary tract infection: J. Kumazawa, F. Matsumoto, ibid. 69-70.

Chemical structure

Properties

Colorless needles from acetonitrile-water, mp 134-135°.

Therapeutic Category

Antibacterial.

Keywords

Antibacterial (Synthetic); Quinolones and Analogs