Human-murine chimeric monoclonal antibody directed against the interleukin-2 receptor α-chain (IL-2Rα), also known as CD25 antigen, on the surface of activated T cells. Prepn: P. L. Amlot et al., EP 449769 (1991 to Sandoz; Roy. Free Hosp. Sch. Med.). Clinical pharmacology: idem et al., Transplantation 60, 748 (1995). Clinical pharmacokinetics: J. Kovarik et al., ibid. 64, 1701 (1997). Clinical trial in kidney transplantation: B. Nashan et al., Lancet 350, 1193 (1997).
Immunosuppressant.
Immunosuppressant