1018. Beclamide

Nomenclature

CAS number: 501-68-8
3-Chloro-N-(phenylmethyl)propanamide; N-benzyl-3-chloropropionamide; N-benzyl-β-chloropropanamide; benzchlorpropamide; chloroethylphenamide; Neuracen (Byk Gulden); Nidrane (Phoenix); Posedrine (Merck KGaA); Seclar (Andromaco).
C10H12ClNO; mol wt 197.66.
C 60.76%, H 6.12%, Cl 17.94%, N 7.09%, O 8.09%.

Description and references

Prepd by the action of β-chloropropionyl chloride on benzylamine in cooled water at pH 8: Cassell, Kushner, US 2569288 (1951 to Am. Cyanamid); Kushner et al., J. Org. Chem. 16, 1283 (1951).

Chemical structure

Properties

Large crystals from methanol, mp 94°. Slightly sol in water (0.005 to 0.01%). Moderately sol in the lower alcs. Dec in hot aq acid soln and in hot aq alkaline soln.

Therapeutic Category

Anticonvulsant.

Keywords

Anticonvulsant