1021. Befloxatone

Nomenclature

CAS number: 134564-82-2
(5R)-5-(Methoxymethyl)-3-[4-[(3R)-4,4,4-trifluoro-3-hydroxybutoxy]phenyl]-2-oxazolidinone; MD-370503.
C15H18F3NO5; mol wt 349.30.
C 51.58%, H 5.19%, F 16.32%, N 4.01%, O 22.90%.

Description and references

Reversible monoamine oxidase type A (MAO-A) inhibitor. Prepn: F. X. Jarreau et al., EP 424244; eidem, US 5036091 (1990, 1991 both to Delalande). Pharmacology: D. Caille et al., J. Pharmacol. Exp. Ther. 277, 265 (1996). Biochemical profile: O. Curet et al., ibid. 253. Structure-activity study: J. Wouters et al., Bioorg. Med. Chem. 7, 1683 (1999). Review of clinical pharmacology: P. Rosenzweig et al., J. Affect. Disord. 51, 305-312 (1998).

Chemical structure

Properties

Crystals from ethanol + isopropyl ether, mp 101°. [α]D20 11.5° (c = 1 in methylene chloride).

Therapeutic Category

Antidepressant.

Keywords

Monoamine Oxidase Inhibitor; Antidepressant; Phenyloxazolidinones