Selective costimulation blocker similar to abatacept, q.v. Soluble fusion protein combining a modified form of the extracellular portion of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) with the constant region of human IgG1. Prepn: R. J. Peach et al., WO 0192337; eidem US 05214313 (2001, 2005 both to Bristol-Myers Squibb). Pharmacology and development: C. P. Larsen et al., Am. J. Transplant. 5, 443 (2005). Clinical trial in rheumatoid arthritis: L. W. Moreland et al., Arthritis Rheum. 46, 1470 (2002); in renal transplantation: F. Vincenti et al., N. Engl. J. Med. 353, 770 (2005).
Immunosuppressant.
Immunosuppressant