1039. Benfluorex

Nomenclature

CAS number: 23602-78-0
2-[[1-Methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]ethanol benzoate (ester); 2-[[α-methyl-m-(trifluoromethyl)phenethyl]amino]ethanol benzoate (ester); 1-(m-trifluoromethylphenyl)-2-(β-benzoyloxyethyl)aminopropane; N-(2-benzoyloxyethyl)norfenfluramine; benfluramate; S-780; SE-780.
C19H20F3NO2; mol wt 351.36.
C 64.95%, H 5.74%, F 16.22%, N 3.99%, O 9.11%.

Description and references

Prepn from 1-(m-trifluoromethyl)-2-(β-hydroxyethyl)aminopropane and benzoyl chloride: L. Beregi et al., FR 1517587; eidem, US 3607909 (1968, 1971 both to Sci. Union et Cie, Soc. Franc. Rech. Med.). Metabolism studies: A. H. Beckett et al., J. Pharm. Pharmacol. 23, 950 (1971); 24, 281 (1972). Pharmacology: D. N. Brindley et al., ibid. 28, 670 (1976); P. Pritchard et al., ibid. 29, 343 (1977); eidem, Biochem. J. 166, 639 (1977).

Chemical structure

Properties

Colorless oil.

Derivative

Hydrochloride.

Nomenclature

CAS number: 23642-66-2
S-992; JP-992; Minolip (Master); Mediator (Biopharma); Mediaxal (Servier).
C19H20F3NO2.HCl; mol wt 387.82.
C 58.84%, H 5.46%, F 14.70%, N 3.61%, O 8.25%, Cl 9.14%.

Properties

Crystals from ethyl acetate, mp 161-162°.

Therapeutic Category

Antilipemic.

Keywords

Antilipemic