1087. Benzoctamine

Nomenclature

CAS number: 17243-39-9
N-Methyl-9,10-ethanoanthracene-9(10H)-methanamine; 1-(methylaminomethyl)dibenzo[b,e]bicyclo[2.2.2]octadiene; 9-(methylaminomethyl)-9,10-dihydro-9,10-ethanoanthracene.
C18H19N; mol wt 249.35.
C 86.70%, H 7.68%, N 5.62%.

Description and references

Prepn: BE 610863; P. Schmidt et al., US 3399201 (1962, 1968 to Ciba); Wilhelm, Schmidt, Helv. Chim. Acta 52, 1385 (1969). Pharmacology: Keberle et al., Present Status Psychotropic Drugs (Excerpta Medica, New York, 1969) p 123; Baltzer, Bein, Arch. Int. Pharmacodyn. Ther. 201, 25 (1973). Toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 10085-81-1
Ba-30803; Tacitin (Novartis).
C18H19N.HCl; mol wt 285.81.
C 75.64%, H 7.05%, N 4.90%, Cl 12.40%.

Properties

Crystals, mp 320-322°. pKa: 7.6. LD50 orally in rats: 700 ±170 mg/kg (Goldenthal).

Therapeutic Category

Anxiolytic.

Keywords

Anxiolytic