1095. 6,7-Benzomorphan

Nomenclature

CAS number: 575-19-9
1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine; 6,7-benzmorphan.
C12H15N; mol wt 173.25.
C 83.19%, H 8.73%, N 8.08%.

Description and references

Parent compound of a series of potent analgetics. Synthesis: Kanematsu et al., J. Am. Chem. Soc. 90, 1064 (1968); Kanematsu et al., J. Med. Chem. 12, 405 (1969). Review of derivative syntheses and pharmacology: May, Sargent, “Morphine and its Modifications”, in Analgetics, G. de Stevens, Ed. (Academic Press, New York, 1965) pp 145-171.

Chemical structure

Derivative

Hydrochloride.
C12H15N.HCl; mol wt 209.72.
C 68.72%, H 7.69%, N 6.68%, Cl 16.90%.

Properties

Needles from methanol-acetone, mp 261-262°.