1136. Benzylhydrochlorothiazide

Nomenclature

CAS number: 1824-50-6
6-Chloro-3,4-dihydro-3-(phenylmethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-benzyl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-chloro-7-sulfamoyl-3-benzyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; 3-benzyl-6-chloro-3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide; Behyd (Kyorin).
C14H14ClN3O4S2; mol wt 387.86.
C 43.35%, H 3.64%, Cl 9.14%, N 10.83%, O 16.50%, S 16.53%.

Description and references

Prepn: Werner et al., J. Am. Chem. Soc. 82, 1161 (1960); Novello et al., J. Org. Chem. 25, 970 (1960); Ugi, US 3108097 (1963).

Chemical structure

Properties

Crystals from acetic acid + water, mp 260-262°. Also reported as crystals from water, mp 269°.

Therapeutic Category

Antihypertensive; diuretic.

Keywords

Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs