1148. Bephenium Hydroxynaphthoate

Nomenclature

CAS number: 3818-50-6
N,N-Dimethyl-N-(2-phenoxyethyl)benzenemethanaminium salt with 3-hydroxy-2-naphthalene carboxylic acid (1:1); bephenium embonate; Lecibis (Columbia).
C28H29NO4; mol wt 443.53.
C 75.82%, H 6.59%, N 3.16%, O 14.43%.

Description and references

Prepn: F. C. Copp, US 2918401 (1959 to Burroughs Wellcome). Mode of action: G. C. Coles et al., Experientia 30, 1265 (1974). Spectrophotometric determn: C. S. P. Sastry, M. Aruna, Pharmazie 43, 361 (1988). Efficacy against strongylosis in elephants: K. Chandrasekharan et al., Kerala J. Vet. Sci. 13, 15 (1982). Clinical trial in hookworm infections: J. Nahmias et al., Ann. Trop. Med. Parasitol. 83, 625 (1989).

Chemical structure

Properties

Crystals, mp 170-171°. Absorption max (water): 600 nm.

Therapeutic Category

Anthelmintic (Nematodes).

Therapeutic Category (Veterinary)

Anthelmintic (Nematodes).

Keywords

Anthelmintic (Nematodes)