1212. Bifluranol

Nomenclature

CAS number: 34633-34-6
rel-4,4′-[(1R,2S)-1-Ethyl-2-methyl-1,2-ethanediyl]bis[2-fluorophenol]; erythro-3,3′-difluoro-4,4′-dihydroxy-α-ethyl-α′-methyldibenzyl; BX-341; Prostarex (Biorex).
C17H18F2O2; mol wt 292.32.
C 69.85%, H 6.21%, F 13.00%, O 10.95%.

Description and references

Orally active antiprostatic agent. Prepn: J. C. Turner, R. P. Chan, DE 2110428; eidem, US 4051263 (1971, 1977 both to Biorex). Antiprostatic activity: J. B. Dekanski, Br. J. Pharmacol. 71, 11 (1980). Chemistry, disposition in animals: D. J. Pope et al., J. Pharm. Pharmacol. 33, 297 (1981). Metabolism: eidem, ibid. 302.

Chemical structure

Properties

Cryst from toluene, mp 158-159°.

Therapeutic Category

Antiandrogen.

Keywords

Antiandrogen