1308. Bitoscanate

Nomenclature

CAS number: 4044-65-9
1,4-Diisothiocyanatobenzene; phenylene-1,4-diisothiocyanate; isothiocyanic acid p-phenylene ester; Jonit (Hoechst).
C8H4N2S2; mol wt 192.26.
C 49.98%, H 2.10%, N 14.57%, S 33.36%.

Description and references

Prepn: Lieber, Slutkin, J. Org. Chem. 27, 2214 (1962). Prepn and use as anthelmintic: FR M1652 and GB 1001314 (1963, 1965 to Hoechst). Purification: Soeder, Laemmer, DE 1172664 (1964 to Hoechst). Series of articles on clinical studies: Progress in Drug Research vol. 19, E. Jucker, Ed. (Birkh"auser Verlag, Basel and Stuttgart, 1975) pp 2-107.

Chemical structure

Properties

Tasteless, odorless, colorless needles, from acetic acid or acetone, mp 132°.

Therapeutic Category

Anthelmintic (Nematodes).

Keywords

Anthelmintic (Nematodes)