1376. Brinzolamide

Nomenclature

CAS number: 138890-62-7
(4R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide; AL-4682; Azopt (Alcon).
C12H21N3O5S3; mol wt 383.51.
C 37.58%, H 5.52%, N 10.96%, O 20.86%, S 25.08%.

Description and references

Carbonic anhydrase inhibitor. Prepn: T. R. Dean et al., WO 9115486; eidem, US 5378703 (1991, 1995 both to Alcon). Clinical trial: L. H. Silver, Am. J. Ophthalmol. 126, 400 (1998).

Chemical structure

Properties

Sol in ethanol.

Derivative

Hydrochloride.

Nomenclature

CAS number: 150937-43-2
C12H21N3O5S3.HCl; mol wt 419.97.
C 34.32%, H 5.28%, N 10.01%, O 19.05%, S 22.91%, Cl 8.44%.

Properties

Crystals from methanol + methylene chloride, mp 175-177°. [α]D +10.35° (c = 1 in water).

Therapeutic Category

Antiglaucoma agent.

Keywords

Antiglaucoma; Carbonic Anhydrase Inhibitor