1379. Brodifacoum

Nomenclature

CAS number: 56073-10-0
3-[3-(4′-Bromo[1,1′-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl]-4-hydroxy-2H-1-benzopyran-2-one; 3-[3-(4′-bromobiphenyl-4-yl)-1,2,3,4-tetrahydro-1-naphthyl]-4-hydroxycoumarin; PP-581; WBA-8119; Talon (Zeneca Ag Prod).
C31H23BrO3; mol wt 523.42.
C 71.13%, H 4.43%, Br 15.27%, O 9.17%.

Description and references

Coumarin analog. Prepn: M. R. Hadler, R. S. Shadbolt, DE 2424806; eidem, US 3957824 (1975, 1976 to Ward, Blenkinsop & Co.); eidem; J. Chem. Soc. Perkin Trans. 1 1976, 1190. Anticoagulant activity: M. R. Hadler, R. S. Shadbolt, Nature 253, 275 (1975). Field trials: B. D. Rennison, A. C. Dubock, J. Hyg. 80, 77 (1978); F. P. Rowe et al., ibid. 81, 197 (1978). Efficacy and toxicity: L. Yuet-Ming, Malays. Agric. J. 52, 1 (1980).

Chemical structure

Properties

Off-white powder, mp 228-230°. Insol in water. Slightly sol in alc, benzene; sol in acetone, chloroform. LD50 orally in male, female field rats: 0.16, 0.18 mg/kg (Yuet-Ming).

Use

Rodenticide.